European 2-a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula
June 1st, 2012
Infection Genetics and Evolution publish this investigation article
Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.
Rodriguez-Campos S., Schürch AC., Dale J., Lohan AJ., Cunha MV., Botelho A., De Cruz K., Boschiroli ML., Boniotti B., Pacciarini M., Garcia-Pelayo MC., Romero B., de Juan L., Dominguez L., Gordon SV., van Soolingen D., Loftus B., Berg S., Hewinson RG., Aranaz A. and Smith NH.