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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine


May 1st, 2012

Microbiology and Immunology publish this investigation article


A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of foot-and-mouth disease (FMD) killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) (50% protective dose) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by the administration of the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine`s efficacy when administered in combination with it




Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..




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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine

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CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine





FACTOR YEAR Q
1.545 2012

NLMID: 7703966

PMID: 22335800

ISSN: 1348-0421



TITLE: CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine


JOURNAL: Microbiol. Immunol.


NUMERACIÓN: 56(5):332-7


AÑO: 2012


PUBLISHER: Wiley-Blackwell Publishing, inc


AUTHORS: Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM..


DOI: http://dx.doi.org/ 10.1111/j.1348-0421.2012.00438.x


CITE THIS PUBLICATION:

Guo X., Jia H., Zhang Q., Yuan W., Zhu G., Xin T., Zhu H. and Sanchez-Vizcaino JM.. CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine. Microbiology and Immunology . 56(5):332-7. 2012. ISSN: 1348-0421. DOI: 10.1111/j.1348-0421.2012.00438.x